[对于神经退行性疾病的高压氧疗法机制和应用的进展]
Fang-Fang Wang1, Nan Wang1, Heng-Rong Yuan1
1Department of Diving and Hyperbaric Medical Research, Naval Medical Center, Naval Medical University, Shanghai 200433, China.
Sheng li xue bao : [Acta physiologica Sinica]
|May 6, 2025
概括
高压氧气疗法 (HBOT) 显示出治疗神经退行性疾病 (NDD) 的前景. 这篇评论探讨了HBOT.
科学领域:
- 神经科学是一个神经科学.
- 高压医学的高压医学.
- 生物医学研究生物医学研究
背景情况:
- 神经退行性疾病 (NDD) 构成了日益严重的全球健康挑战,预计到2040年将成为第二大死亡原因.
- 目前对NDD的治疗策略有限,需要探索新的治疗干预措施.
- 高压氧疗法 (HBOT) 传统上用于减压疾病等疾病,已成为神经系统疾病的潜在治疗方法.
研究的目的:
- 审查目前对NDD病原和现有治疗方法的理解.
- 评估HBOT在管理NDD中的应用和潜力.
- 探索HBOT在NDD治疗中的有效性的潜在机制.
主要方法:
- 对有关NDD病原和治疗的现有文献的综述.
- 在NDD动物模型中研究HBOT的研究分析.
- 对HBOT临床试验数据进行NDD和相关认知障碍的检查.
主要成果:
- 在脑损伤和中风后,HBOT在改善认知功能方面表现出积极的影响.
- 有证据表明,HBOT可以缓解与NDD相关的神经退行和功能障碍.
- 该评论涵盖了HBOT对线粒体功能,神经炎症,神经发生,氧化应激,亡,微循环和NDD中的表观遗传学的影响.
结论:
- 在神经退行性疾病中,HBOT是一个有前途的治疗策略.
- 对HBOT的机制和NDD的临床应用有必要进行进一步的研究.
- 对细胞和分子通路的多方面的HBOT影响为新的NDD干预提供了潜力.
相关概念视频
01:16Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
95
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
95
00:49The Blood-brain Barrier
46.2K
Overview
46.2K
01:23Hypoxia
839
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
839