[心血管疾病中的NAD代谢]
Zhao-Zhi Wen1, Yi-Hang Yang1, Dong Liu1,2
1Nantong Laboratory of Development and Diseases, School of Life Science, Nantong University, Nantong 226000, China.
Sheng li xue bao : [Acta physiologica Sinica]
|May 6, 2025
概括
提高尼古丁胺胺氨基二核酸 (NAD+) 水平可能会改善心血管健康. 本综述探讨了NAD+机制,其在高血压和动脉样硬化等血管疾病中的作用,以及潜在治疗策略的NAD+前体.
科学领域:
- 生物化学 生物化学
- 心脏病学 心脏病学
- 代谢研究研究 代谢研究
背景情况:
- 心血管疾病 (CVD) 是全球首要的死亡原因.
- 尼古丁胺胺氨基二核酸 (NAD+) 是细胞能量,DNA修复和信号传输中的关键代谢物.
- 随着年龄的增长和诸如肥胖和高血压等疾病,NAD+水平下降,这是主要的心血管疾病风险因素.
研究的目的:
- 审查对血管健康至关重要的NAD+相关机制.
- 总结关于血管疾病 (高血压,动脉样硬化,冠状动脉疾病) 中NAD+的研究.
- 评估用于预防和治疗心血管疾病的NAD+前体.
主要方法:
- 关于血管健康和疾病中的NAD+机制的文献综述.
- 对NAD+提升策略的临床前和临床研究的分析.
- 在各种心血管疾病模型中评估NAD+前体的疗效.
主要成果:
- 治疗性NAD+升高减少炎症,增强自,线粒体生物发生和血管细胞中的抗氧化.
- 在动物模型中增加NAD+可以改善健康状况,预防代谢综合征,降低血压.
- 在动物模型和人类中,NAD+策略在改善心脏和血管健康方面表现有前途.
结论:
- NAD+ 在维持血管健康方面发挥着关键作用.
- NAD+前体为预防和治疗主要心血管疾病提供了潜在的治疗途径.
- 对NAD+前体的进一步研究可以指导心血管健康的新策略.
相关概念视频
Directional Terms
7.7K
Directional terms are essential for describing the relative locations of different body structures. For instance, an anatomist might describe one band of tissue as "inferior to" another, or a physician might describe a tumor as "superficial to" a deeper body structure. These terms often use comparative terms in pairs to trace out the relative locations of one body part to another or descriptions of body tissues like the deeper ones from superficially present with reference to...
7.7K
Upward Impending Motion
227
A square-threaded screw jack is a mechanical device widely used for lifting heavy loads or applying considerable force. Its operation is based on converting the force applied at its handle into a torsional moment, causing the upward impending motion of the screw. This movement is accomplished by overcoming the static friction between the threads of the screw and the jack.
To better comprehend how a screw jack functions, consider the completely unraveled thread as a block in contact with the...
To better comprehend how a screw jack functions, consider the completely unraveled thread as a block in contact with the...
227
Additional Subnuclear Structures
2.1K
2.1K
Abdominal Aorta
450
Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
The celiac trunk, a singular artery, divides into the left gastric artery, which...
450
Transcription Elongation Factors
3.3K
3.3K
The Arch of Aorta
457
The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
Encircling the heart, the coronary arteries form a ring-like structure before...
457


