[孕妇患有 ABO 血型分类困难的患者的基因型和输血策略]
Chen-Chen Feng1, Qing Chen2, Xiao Wei3
1Jiangsu Province Blood Center, Nanjing 210042, Jiangsu Province, China.
Zhongguo shi yan xue ye xue za zhi
|May 6, 2025
概括
在孕妇中,ABO血型亚型使识别变得复杂. 基因测序准确地确定血型,确保安全的输血和母胎健康.
科学领域:
- 血液学 血液学 血液学
- 遗传学 是一个遗传学.
- 产科 产科 产科 产科 产科
背景情况:
- 准确的血型测定对于安全的输血至关重要,特别是在孕妇患者中.
- 由于罕见的亚型和与怀孕有关的生理变化,可能会出现ABO血型差异.
- 难以类型化的 ABO 血型在输血医学中带来了挑战.
研究的目的:
- 在孕妇患者中识别特定的 ABO 血型亚型,具有具有挑战性的血型分类结果.
- 为了将遗传发现与血清学观察相关联.
- 为在这个患者群体中提供安全输血实践指导.
主要方法:
- 收集了36名怀孕患者的血液样本,这些患者具有可疑的ABO血型.
- 采用血清学方法和基因测序来进行血型表型化和基因型化.
- 已使用的样本在两年内提交给中央遗传测试平台.
主要成果:
- 在36个样本中检测到20种不同的ABO亚型.
- 常见的亚型包括BA/O (10例) 和cisAB/O (3例).
- 确定了4例巴巴姆拜血型;12例没有显示出特定异常变异.
结论:
- 在怀孕期间,ABO亚型显著干扰了准确的ABO血型识别.
- 怀孕本身可以影响血型表型表达.
- 基因测序对于精确的基因型确定,指导安全输血和确保母婴福祉至关重要.
更多相关视频
07:24A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
1.7K
05:23Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
19.2K
相关概念视频
Blood Transfusion and Agglutination
10.6K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.6K
Blood Typing
1.0K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.0K
Blood Types
17.1K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.1K
Blood Transfusion
422
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
422
Rh Blood Group
1.2K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.2K
Bone Marrow Sampling and Transplants
260
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
260
