两种氨基酸-酸乳连合物来自西瓜根及其抗炎活性
Xiuhua Meng1, Xiaojie Huang1, Yang Liu1
1Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Memorial Sun Yat-Sen), Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Nanjing, China.
Natural product research
|May 6, 2025
概括
香草根产生了一种新型的氨基酸-酸乳结合物,11β,13-二-13-prolyl-lactucin. 这种化合物和另一种化合物通过抑制氧化的产生表现出显著的抗炎作用.
科学领域:
- 植物化学 植物化学
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在历史上,Cichorium intybus L. () 已被认为具有营养和治疗用途.
- 酸乳是香草中主要的生物活性成分.
- 香草根的化学成分,特别是新型结合物,需要进一步研究.
研究的目的:
- 发现和分离从香草根中获得的新型化合物.
- 描述新化合物的结构和绝对立体化学.
- 评估隔离化合物的抗炎潜力.
主要方法:
- 从Cichorium intybus根中提取和分离化合物.
- 广泛的光谱研究 (NMR,MS等) 用于结构阐明.
- 实验和理论电子循环二元化 (ECD) 光谱用于绝对立体化学的确定.
- 在体外使用脂聚糖 (LPS) 诱导的RAW264.7巨体进行抗炎试验.
主要成果:
- 在根中首次发现了氨基酸-酸乳联合.
- 隔离和结构确定一个新的化合物,11β,13-dihydro-13-prolyl-lactucin (1).
- 这两种分离的化合物都显著抑制了氧化 (NO) 生产.
- 化合物1对NO抑制的IC50值为20.14μM.
- 化合物降低了关键炎症因子TNF-α,IL-6和COX-2的表达.
结论:
- 在根中发现了一种新的氨基酸-酸乳结合物,包括一种新的化合物.
- 新的化合物,11β,13-二-13-基乳素,具有显著的抗炎性质.
- 这些发现凸显了香草成分作为抗炎剂的潜力.
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