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在Bifidobacterium上逐层沉积抗原,用于肠下淋巴系统引导的个性化瘤免疫疗法

Zhu Chen¹, You-Teng Qin¹, Qian-Ru Li¹

¹Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.

Advanced materials (Deerfield Beach, Fla.)

|May 6, 2025

概括

一种新的口服瘤疫苗,Bifidobacterium-抗原氧化 (Bif-OVA-Ocur),有效地刺激肠道免疫力以抑制瘤. 这种非侵入性方法诱导了粘膜和全身反应,在小鼠模型中没有观察到毒性.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
胃肠病学胃肠病学

背景情况:

肠关联淋巴组织 (GALT) 是免疫反应的关键部位.
口服疫苗为治疗干预提供了一个非侵入性的策略.

研究的目的:

通过使用GALT开发和评估一种新的口服疫苗 (Bif-OVA-Ocur) 用于瘤治疗.
诱导肠道粘膜和全身免疫力对抗瘤.

主要方法:

一种基于Bifidobacterium的口服疫苗 (Bif-OVA-Ocur) 通过对抗原 (OVA) 和氧化 (Ocur) 的层次涂层进行了工程设计.
该疫苗被口服给小鼠模型,以评估其针对佩耶斑块 (PPs) 的向性和随后在中腔淋巴结 (MLNs) 中免疫细胞的激活.

主要成果:

Bif-OVA-Ocur成功地将疫苗导向肠道PP,并激活T细胞反应的抗原呈现细胞 (APC).
该疫苗显著提高了分泌IgA (SIgA) 的产生,并引起了强大的粘膜和全身免疫反应.
在没有全身毒性治疗的小鼠中观察到有效的瘤抑制和对瘤挑战的抵抗力.

结论:

这种Bif-OVA-Ocur疫苗有效地利用GALT诱导抗瘤免疫力.
这种非侵入性口服疫苗策略对癌症治疗和未来口服疫苗的开发具有前景.

关键词:

这是一种 bifidobacterium 细菌.交叉表示交叉呈现.肠道粘膜免疫肠道粘膜免疫中腔淋巴结中腔淋巴结.这是一种口服疫苗.

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