丹麦的阿片类药物和二类药物中毒:丹麦毒素信息中心的回顾性研究
Alba K V Sigfredsson1, Dorte Fris Palmqvist2, Kim Dalhoff1,3
1Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Basic & clinical pharmacology & toxicology
|May 6, 2025
概括
在2014-2022年期间,丹麦的阿片类药物和二类药物中毒事件显著增加,特别是阿尔普拉佐拉姆和氧化. 其他毒品中毒事件保持稳定或下降,调整以整体调查增加.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 阿片类药物和二类药物广泛用于治疗疼痛,失眠和焦虑.
- 这些药物带有滥用,成和中毒的风险.
- 了解中毒趋势对于公共卫生干预至关重要.
研究的目的:
- 分析2014年至2022年向丹麦毒素信息中心 (DPIC) 报告的阿片类药物和类类类药物中毒的趋势.
- 识别具有增加或减少中毒率的特定物质.
- 为有针对性的预防战略提供数据.
主要方法:
- 追溯观察登记册研究.
- 从丹麦毒药信息中心 (DPIC) 收集的数据.
- 对涉及九种特定物质的中毒事件的分析:阿尔普拉佐拉姆,克洛纳泽帕姆,氧泽帕姆,布普伦诺芬,二甲,甲,吗啡,氧科登和特拉马多尔.
主要成果:
- 总共有10965个中毒调查被分析.
- 对阿尔普拉佐拉姆 (+416%) 和氧化 (+352%) 的中毒病例有显著的增加.
- 其他物质 (如布普伦诺芬,吗啡,氧泽,特拉马多尔,克洛纳泽和二甲吗啡) 的中毒增加较小或保持稳定,而甲的中毒减少.
结论:
- 从2014年到2022年,阿尔普拉佐拉姆和氧化中毒事件大幅增加.
- 对其他研究的阿片类药物和二类药物的趋势没有显著的变化或调整为整体调查量时的减少.
- 这些发现凸显了对特定药物中毒的监测和有针对性的干预措施的需要.
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