开发用于生物医疗应用的多功能zwitterionic-xanthan固定的网络共聚物

科学领域:

• 材料科学 材料科学 材料科学
• 聚合物化学 聚合物化学
• 生物医学工程 生物医学工程

背景情况:

• 克桑 (XG) 是一种细菌多糖,由于其生物相容性,正在探索用于药物输送.
• 开发先进的水凝系统对于有效和有针对性的药物输送至关重要,特别是对于胃肠道应用.
• 基聚合物具有独特的特性,如生物相容性和粘合性,使其对生物医学应用具有吸引力.

研究的目的:

• 合成和描述新的粘膜粘合剂和生物相容的水凝.
• 研究这些水凝作为胃肠道应用中的药物输送载体的潜力.
• 为了增强水凝特性,将多 (MEDSAH) 移植到香上.

主要方法:

• 自由基移植聚合聚合聚合物 (MEDSAH) onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto onto which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which which
• 使用XRD,FTIR,13C-NMR,TGA-DSC,FESEM,EDX和AFM进行表征.
• 评估药物释放动力学 (甲),生物粘附性,生物相容性 (血液溶解试验) 和抗氧化活性 (DPPH试验).

主要成果:

• 通过光谱和元素分析证实了MEDSAH的成功移植到XG骨干上.
• 与原生XG相比,产生的水凝表现出异质的形态,表面粗度和改变的热特性.
• 经过非Fickian扩散动力学 (Higuchi模型) 观察到埃尔塔胺的受控释放,具有显著的粘膜粘附性,生物相容性和抗氧化特性.

结论:

• 开发的基于香甘的zwitterionic水凝具有有利的物理化学和生物医学特性.
• 这些水凝显示出作为有效的药物输送载体在胃肠道应用中具有显著的潜力.
• 粘膜粘合,生物相容性和受控的药物释放的组合使这些材料在治疗用途中非常有前途.