考赫反流症评分的实际验证:西班牙裔美国患者的多中心研究
Luis G Alcala-Gonzalez1,2, Alberto Ezquerra-Duran3, Francisco Alejandro Félix Téllez4
1Digestive System Research Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
Neurogastroenterology and motility
|May 6, 2025
概括
在COUGH RefluX得分有效地识别胃食道逆流病 (GERD) 的可能性在患有喉回流症状 (LPS) 的患者. 这种非侵入性工具有助于分层患者并优化诊断测试.
科学领域:
- 胃肠病学 胃肠病学
- 反流性疾病 反流性疾病
- 诊断工具 诊断工具 诊断工具
背景情况:
- 喉回流症状 (LPS) 通常被认为源于胃食道回流疾病 (GERD),但客观测试在少数病例中证实了GERD.
- 以前在其他人群中验证的COUGH RefluX评分提供了一种非侵入性方法来评估LPS患者的GERD概率.
- 这项研究评估了COuGH RefluX评分在西班牙裔美国人队列中的实用性.
研究的目的:
- 为了评估COuGH RefluX得分在现实世界西班牙裔美国人群中LPS的表现.
- 为了比较COUGH RefluX评分的原始版本和实际版本的诊断准确性.
- 为了确定得分能够识别具有显著症状-反流关联的患者.
主要方法:
- 这是一项多中心的回顾性队列研究,涉及来自西班牙和拉丁美洲的459名LPS成年患者.
- 患者接受了内镜检查,高分辨率食道测量和24小时pH或pH阻抗监测.
- 计算了COuGH RefluX评分的两种版本:原始 (内镜和计量) 和实用 (仅内镜),GERD状态根据里昂2.0标准定义.
主要成果:
- 经过验证的GERD在36%的患者中得到证实.
- 原来的COUGH RefluX评分显示AUC为0.706 (89%的灵敏度,89%的特异性);实际版本显示AUC为0.684 (89%的灵敏度,89%的特异性).
- 实际得分错误分类了54名患者,主要是由于未检测到的椎间,15例最初不确定的病例被降级.
结论:
- 考赫反流得分有效地分层了LPS患者的GERD概率.
- 评分可能有助于识别具有强烈症状反流相关性的患者,指导进一步的调查和治疗.
- 这种务实的工具可以通过减少对低风险个体不必要的侵入性测试来改善资源分配.
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