双酸盐和诺苏马布对牙科植入物的影响:通过元分析进行系统性审查
Linni Lin1, Yijie Ren2, Xia Wang1
1Center of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Oral diseases
|May 6, 2025
概括
双酸盐 (BP) 可能会增加牙植入物衰竭和与药物相关的骨瘤 (MRONJ) 的风险. 有证据表明,BP与边际骨损失无关,而denosumab与此无关.
科学领域:
- 口腔和牙面部外科手术
- 药理学 药理学是指药理学的学科.
- 生物材料科学 生物材料科学
背景情况:
- 双酸盐 (BP) 和代诺苏马布是影响骨代谢的常见处方药.
- 它们对牙植入物结果的影响,包括失败 (IF),边缘骨损失 (MBL) 和与药物相关的下巴骨硬化 (MRONJ),需要进行彻底评估.
- 了解这些关联对于植入式牙科的患者管理和治疗计划至关重要.
研究的目的:
- 系统地审查和评估双酸盐 (BP) 和丹诺苏马布对牙植入物的影响.
- 具体评估与植入物衰竭 (IF),边缘骨损失 (MBL) 和与药物相关的下巴骨硬化 (MRONJ) 的关联.
- 综合当前的证据,以告知牙科植入物患者对这些药物的临床决策.
主要方法:
- 在四个数据库和OpenGrey进行了全面的文献搜索.
- 纳入标准侧重于研究IF,MBL或MRONJ与BP或登苏马布使用相关的研究.
- 使用ROBINS-I评估偏差风险;用试验顺序分析和GRADE方法评估证据的确定性.
主要成果:
- 审查中包括了21项研究.
- 双酸盐 (BP) 与植入物水平 (RR 1.74) 的植入物失败 (IF) 有关,但与患者水平无关.
- 血压显示与MRONJ有显著的关联 (RR 3.45),但与MBL没有显著的相关性. 德诺苏马布没有与MRONJ显著的统计相关性.
结论:
- 现有证据表明,尽管确定性很低,但BP摄入可能会增加牙科植入物患者的IF和MRONJ风险.
- 双酸盐 (BP) 似乎与边际骨损失 (MBL) 无关.
- 德诺苏马布和MRONJ之间的关联仍然是未知的.
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