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长非编码RNA作为冠状动脉疾病潜在的诊断工具 - - 一项系统性审查

As Arthi Sri^1,2, V P Veeraraghavan¹, S Patil³

¹Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

Nigerian journal of clinical practice

|May 6, 2025

概括

长非编码RNAs (lncRNAs) 显示了冠状动脉疾病 (CAD) 的高诊断准确性. 像KCNQ1OT1和OTTHUMT00000387022这样的特定lncRNA显示出作为可靠的CAD检测生物标志物的巨大潜力.

科学领域:

生物分子研究的研究.
心血管医学心血管医学
基因组学和转录基因组学

背景情况:

冠状动脉疾病 (CAD) 是一个主要的全球健康问题.
长非编码RNAs (lncRNAs) 越来越多地被认为是它们在疾病发病过程中的作用和潜在的生物标志物.
识别可靠的生物标志物,用于早期和准确的CAD诊断至关重要.

研究的目的:

系统地审查和评估 lncRNAs作为冠状动脉疾病 (CAD) 生物标志物的诊断准确性.
为了确定特定的lncRNAs具有高灵敏度和特异性,用于CAD检测.

主要方法:

按照PRISMA指南进行了系统审查.
分析了22项涉及5301名参与者的研究.
对已识别的 lncRNAs 进行了诊断准确度指标 (灵敏度和特异性) 的评估.

主要成果:

27个lncRNA被确定为CAD的潜在生物标志物.
KCNQ1OT1,HIF1A-AS2和APOA1-AS表现出高的诊断准确性 (100%的灵敏度,80%的特异性).
OTTHUMT00000387022显示了最高的特异性 (98%),在所有研究中,总体灵敏度和特异性分别达到100%和98%.

结论:

lncRNAs作为冠状动脉疾病的非侵入性诊断生物标志物具有显著的潜力.
已识别的lncRNAs,特别是KCNQ1OT1,HIF1A-AS2,APOA1-AS和OTTHUMT00000387022,显示出有希望的诊断实用性.
对lncRNA的进一步研究可能会导致新的CAD诊断工具和治疗策略.

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