可穿戴的光子设备用于多种生物标志物采样和检测,无需抽血
Zuan-Tao Lin1, Biswabandhu Jana1, Sandeep Korupolu1
1Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston, MA, 02114, USA.
Advanced materials (Deerfield Beach, Fla.)
|May 6, 2025
概括
这项研究引入了一种无针的可穿戴光子设备,用于血液生物标志物检测. 它使用光来增强皮肤中的生物标志物度,以进行无痛,敏感的分析.
科学领域:
- 生物光子学和生物感知学
- 最少侵入性诊断的诊断方法
- 可穿戴的健康技术
背景情况:
- 传统的瘤手术涉及针头,造成疼痛和不便.
- 现有的诊断方法往往缺乏敏感性或需要侵入性手术.
- 需要使用非侵入性,准确和用户友好的生物标志物检测方法.
研究的目的:
- 开发一种可穿戴的光子设备,用于无针针的血液生物标志物采样和检测.
- 通过血液生物标志物实现无痛和方便的健康状况监测.
- 为了实现生物标志物的高灵敏度和多重检测.
主要方法:
- 微镜阵列 (MLA) 和光学微针阵列 (OMNA) 的集成,具有免疫约束功能.
- 使用595nm的LED光来增强皮肤中的生物标志物扩散.
- 在OMNA上进行特定抗体固定,用于有针对性的生物标志物捕获和信号放大.
主要成果:
- 该设备成功地将光放大并传输到皮肤中,而不管皮肤颜色如何.
- 照明增加了毛细血管生物标志物度,通过热扩张和扩散.
- 在小鼠模型中,与酶相关免疫吸收试验 (ELISA) 套件相比,已显示出更高的灵敏度.
结论:
- 可穿戴的光子设备为生物标志物采样提供了一种安全有效的无针方法.
- 该技术能够精确,最小侵入性和多重检测血液生物标志物.
- 在小鼠模型中得到验证,用于量化炎症和抗体产生,显示出诊断潜力.
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