在患有慢性鼻炎的非喘儿童和青少年中,对鼻腔和肺功能进行比较分析
Ricardo J Saranz1,2, Mariana Sacco Ramello1,2, Selene Pury1,2
1Chair of Immunology, Facultad de Ciencias de la Salud, Universidad Católica de Córdoba, Córdoba, Argentina.
Archivos argentinos de pediatria
|May 6, 2025
概括
在没有喘的慢性鼻炎的儿童中,鼻腔阻塞与肺功能相关,特别是在过敏性鼻炎病例中. 鼻腔乙酸细胞与鼻腔或肺功能没有相关性.
科学领域:
- 儿科 儿科 儿科
- 肺部病理学 肺部病理学
- 过敏学 过敏学
背景情况:
- 鼻腔阻塞是慢性鼻炎的一个关键症状.
- 之前的研究将鼻腔阻塞和支气管阻塞与喘相关联.
- 在没有喘的鼻炎中,鼻腔阻塞和肺功能之间的关系没有得到充分的研究.
研究的目的:
- 检查患有慢性过敏性鼻炎 (AR) 和无喘非过敏性鼻炎 (NAR) 的儿童和青少年鼻腔和肺功能之间的相关性.
- 在AR患者中,调查鼻色素细胞计数 (NSEo) 和鼻/肺功能之间的联系.
主要方法:
- 包括77名患有AR或NAR (没有喘) 的儿童和青少年 (7-16岁).
- 通过峰值鼻吸气流 (PNIF z-score) 评估鼻功能.
- 通过螺旋计测量肺功能 (FEV1,FEF25-75%的z分数).
- 在AR患者中进行的鼻胆固醇细胞计数.
主要成果:
- 在总样本中发现PNIF和FEF25-75% (p=0.007) 和FEV1 (p=0.009) 之间存在正相关性.
- 在AR小组中,这种相关性更强 (PNIF与FEF25-75%,r=0.351;PNIF与FEV1,r=0.294).
- 在AR患者中,没有观察到NSEos和PNIF,FEF25-75%,或FEV1之间的显著相关性.
结论:
- 在没有喘的儿科慢性鼻炎患者中,鼻吸气流与肺功能相关.
- 鼻腔和肺功能之间的相关性在过敏性鼻炎中更加明显.
- 在这个人群中,鼻色素水平与鼻子或肺功能无关.
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