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药物释放支架与裸金属支架用于症状性内狭窄症:一个比较的系统性审查和元分析研究

Mohammad Sina Mirjani¹, Pouria Delbari², Muhammad Hussain Ahmadvand²

¹Student Research Committee, Qom University of Medical Sciences, Qom, Iran.

European journal of clinical pharmacology

|May 6, 2025

概括

与裸体金属支架 (BMS) 相比,药物排泄支架 (DES) 在症状内动脉硬化支架 (sICAS) 的患者中显著降低了支架内静脉缩和主要中风. DES为SICAS管理提供了更好的结果.

科学领域:

神经学神经学
心血管医学心血管医学
干预性放射学干预性放射学

背景情况:

内动脉硬化狭窄症 (ICAS) 是全球缺血性中风的主要原因.
ICAS与治疗结果不佳有关,包括中风复发率高和功能残疾.
支架是ICAS的治疗选择,但存在关于并发症和支架内缩 (ISR) 的担忧.

研究的目的:

为了比较药物释放支架 (DES) 与裸金属支架 (BMS) 的疗效和安全性,用于治疗症状性ICAS (sICAS).

主要方法:

一个系统的审查和元分析,遵循PRISMA指南.
搜索的主要数据库 (PubMed,Embase,科学网) 到2024年3月.
包括44项涉及13,658名患者的研究,分析技术/临床成功,并发症,ISR和中风率.

主要成果:

与BMS相比,DES显示较低的大型中风 (3%vs. 5%) 和ISR (8%vs. 19%) 的汇总率,尽管中风率差异并不显著.
临床成功率相似 (89%的DES与BMS相比为86%).
这两种支架类型的技术成功率很高,相似;异质性因素包括支架尺寸.

结论:

药物排泄支架 (DES) 在降低ISR和SICAS中主要中风率方面比裸金属支架 (BMS) 具有显著的优势.
DES保持了可比的安全性和技术成功,支持它们在SICAS管理中的优先使用.
在SICAS中使用DES可以通过最大限度地减少复原和复发性缺血事件来提高患者的治疗结果.

关键词:

动脉样硬化是一种动脉样硬化.缺血缺血是因为缺血.狭窄症 (英语:Stenosis) 是一种缩小症.支架是一种支架.一次性中风,中风.

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