患癌症的食道切除术后良性静脉狭窄症的危险因素
Dillen C van der Aa1,2,3, Jelle Boonstra4, Wietse J Eshuis4,5,6
1Department of Surgery, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands. d.c.vanderaa@amsterdamumc.nl.
Annals of surgical oncology
|May 6, 2025
概括
消化管切除术后良性静脉缩与静脉漏和特定的外科手术技术有关. 免疫抑制剂和慢性肺病等危险因素增加了狭窄的发生,影响了患者的生活质量.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 胸部外科手术 胸部外科手术
背景情况:
- 良性静脉静脉狭窄是食道切除术后的常见并发症,导致消化不良和降低生活质量.
- 鉴定良性静脉静脉狭窄症的危险因素对于改善癌症食道切除术后的患者结果至关重要.
研究的目的:
- 为了确定与癌症的食道切除术后良性静脉静脉狭窄症的发展相关的预测因素.
- 单独分析胸内瘤和宫瘤的风险因素.
主要方法:
- 在2012年至2022年期间,对902名接受食道切除术的患者进行了回顾性队列研究.
- 分析胸内和宫静脉瘤,通过食障碍和扩张需要来定义狭窄.
- 后勤回归被用来确定狭窄症的预测因素.
主要成果:
- 在宫 (49.8%) 和胸内 (18.4%) 的静脉瘤中观察到较高的静脉缩率 (p < 0.001).
- 胸内狭窄症与静脉漏 (OR,2.034),较小的紧固件尺寸 (OR,0.486),免疫抑制剂 (OR,3.492) 和慢性肺部疾病 (OR,2.717) 有关.
- 对于宫解剖,手工端到侧技术具有保护性 (OR,0.454),而免疫抑制剂和COPD增加了风险.
结论:
- 胸内狭窄症的关键危险因素包括静脉漏,较小的紧固件尺寸,免疫抑制剂的使用和慢性肺部疾病.
- 对于宫静脉瘤,手工的端到侧技术是保护性的,而免疫抑制剂和慢性肺病会增加狭窄风险.
更多相关视频
相关概念视频
Esophageal Strictures-I: Introduction
35
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
35
Esophageal Strictures-II: Clinical Features and Management
18
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
18
Barrett Esophagus-I: Introduction
35
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
35
Esophageal Varices-I: Introduction
45
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
45
Barrett Esophagus-II: Clinical Manifestations and Management
71
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
71
Esophageal Perforation-I: Introduction
40
Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
40


