在卵巢刺激方案期间抑制排卵的口服GnRH抗体:系统性审查和元分析
Nadav Cohen1,2,3, Ariel Zilbelicht4,5, Chen Nahshon4,5
1Division Reproductive Endocrinology, Lady Davis Carmel Medical Center, Haifa, Israel. nadavco@clalit.org.il.
Journal of assisted reproduction and genetics
|May 6, 2025
概括
口服性腺激素释放激素 (GnRH) 反对剂在试管婴儿不孕症治疗中显示出潜在的益处. 然而,需要进一步的研究来确认它们在临床实践中的有效性和安全性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
背景情况:
- 口服性腺激素释放激素 (GnRH) 抗剂对体外受精 (IVF) 结果的临床影响需要进一步澄清.
- GnRH抗剂用于受控卵巢刺激方案,以防止过早的黄激素激增.
研究的目的:
- 系统地审查和元分析口服GnRH抗体对试管婴儿治疗结果的影响.
- 在试管婴儿周期中,评估口服GnRH抗剂与注射GnRH抗剂的疗效和安全性.
主要方法:
- 在主要数据库 (MEDLINE,PubMed,Embase,Web of Science,Cochrane Library) 进行了全面的电子文献搜索,截至2024年12月16日.
- 包括的研究是实验性和非实验性,评估口服GnRH对抗剂在受控的卵巢刺激.
- 主要结局包括周期取消率和获得成熟卵细胞的平均数量.
主要成果:
- 四项涉及813名患者的研究被纳入了分析.
- 在口服和注射GnRH抗剂之间,没有观察到周期取消率,卵细胞产量,受精或爆发率的统计学上显著差异.
- 根据GRADE标准,证据的整体质量被评为中等.
结论:
- 这一系统性审查和元分析是首次检查口服GnRH对抗剂在IVF中抑制排卵.
- 研究结果表明,口服GnRH抗剂在不孕症治疗中具有潜在的益处.
- 需要进一步的临床验证,以确定口服GnRH抗剂的最终有效性和安全性.
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