口服,诺福维尔基的艾滋病毒暴露前预防的坚持措施的表现:系统性审查
Diana Zeballos1, Nathalia Sernizon Guimarães2, Marcos Pereira3
1Instituto de Saúde Coletiva, Universidade Federal da Bahia. Salvador, Bahia, Brazil. dianazeballos@gmail.com.
AIDS and behavior
|May 6, 2025
概括
准确的艾滋病毒暴露前预防 (PrEP) 遵守措施至关重要. 这次审查发现,与自我报告一样的间接坚持方法显示出混合的准确性和异质性,限制了它们用于识别低坚持的临床使用.
科学领域:
- 药理学和制药学 药理学和制药学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 对艾滋病毒暴露前预防 (PrEP) 进行准确的坚持测量对于患者的支持至关重要.
- 间接遵守措施是常用的,但它们的性能需要评估.
研究的目的:
- 系统地审查每日口服PrEP (特诺福维尔二松醇烟酸/emtricitabine) 的间接坚持措施的性能.
- 探索这些间接措施的临床效用.
主要方法:
- 使用间接措施 (自我报告,药丸计数等) 评估PrEP遵守率的研究的系统审查. 与直接措施 (血液中药物水平) 相反.
- 搜索了PubMed,Embase,LILACS,科学网;使用QUADAS-2评估了偏差风险.
主要成果:
- 包括23项研究 (6649名参与者);大多数是观察性的,自我报告是最常见的间接措施.
- 间接测量表明在识别保护性药物水平 (TFV-DP) 中存在显著的异质性和混合精度.
- 偏差风险和适用性问题通常很低或由于报告不清楚.
结论:
- 间接遵守PrEP的措施,特别是自我报告,被广泛使用,但显示出相当大的异质性和可变的准确性.
- 目前的证据限制了这些措施的广泛临床适用性,用于识别需要坚持支持的个体.
- 需要进一步的研究来开发和验证可靠的PrEP间接遵守措施.
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