免疫抑制治疗在自身免疫性视网膜病变中的临床结果
Seok Hyeon Song1, Min Seok Kim1, Seok Hyun Bae1,2
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Ocular immunology and inflammation
|May 6, 2025
概括
长期免疫抑制疗法对自身免疫视网膜病变 (AIR) 患者显示出不良结果. 复原抗体增加了视力损伤的风险,但ARA水平没有预测视力或OCT变化.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 视网膜疾病 视网膜疾病
背景情况:
- 自身免疫视网膜病变 (AIR) 是一种免疫媒介的疾病,影响视力.
- 免疫抑制疗法是对AIR的常见治疗方法,但其长期疗效仍有争议.
研究的目的:
- 评估AIR患者免疫抑制治疗的长期结果.
- 评估抗视网膜抗体 (ARA) 资料对治疗结果的影响.
主要方法:
- 对26名AIR患者进行了回顾性多中心观察性研究,治疗时间≥6个月.
- 从2011年3月到2023年11月收集的临床,眼科和ARA个人资料数据.
- 分析了使用回归分析的治疗前和治疗后眼科检查结果.
主要成果:
- 平均治疗持续时间为25.3个月,61%的眼睛显示最佳校正视敏度 (BCVA) 恶化.
- 平均BCVA显著下降 (0.67至1.07 logMAR,p<0.001);OCT显示35%的眼睛恶化.
- 电网红图没有改善;66%的眼睛视野恶化;与较高视力损伤风险相关的抗体恢复.
结论:
- 在AIR患者中,长期的免疫抑制疗法产生了不良的功能和解剖结果.
- 康沃林抗体与视力损伤风险增加有关.
- ARA的数量与BCVA或OCT恶化没有显著的相关性.
相关概念视频
Coagulation
1.5K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.5K
Coagulation
8.4K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
8.4K


