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相关概念视频

Polygenic Traits01:18

Polygenic Traits

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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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Pleiotropy01:33

Pleiotropy

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Energy Budgets00:51

Energy Budgets

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Organisms must balance energy intake with the energy required for growth, maintenance and reproduction. These trade-offs result in a variety of survivorship and reproductive strategies, including semelparity and iteroparity. Semelparous species, like annual plants, have only one reproductive episode in their lifetimes and consequently have short lifespans. Iteroparous species, by contrast, have many reproductive events during their lifetimes but have relatively few offspring. These two...
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Position-effect Variegation02:32

Position-effect Variegation

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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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Production Efficiency01:01

Production Efficiency

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Net production efficiency (NPE) is the efficiency at which organisms assimilate energy into biomass for the next trophic level. Due to low metabolic rates and less energy spent on thermoregulatory processes, the NPE of ectotherms (cold-blooded animals) is 10 times higher than endotherms (warm-blooded animals).
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相关实验视频

Updated: May 9, 2025

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
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Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

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独特的能量特征与持久的薄型现象型相关.

Mélina Bailly1, David Thivel1, Laurie Isacco1

  • 1Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques (AME2P), CRNH Auvergne, Université Clermont Auvergne, Clermont-Ferrand, France;

Annual review of nutrition
|May 6, 2025
PubMed
概括
此摘要是机器生成的。

宪法上的瘦身,健康的体重不足状态,挑战了新陈代谢概念. 了解这种持久的薄型表型可能会提供对抗肥胖的保护性代谢模式的见解.

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Three-Dimensional Culture of Vascularized Thermogenic Adipose Tissue from Microvascular Fragments
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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
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相关实验视频

Last Updated: May 9, 2025

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
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Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

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Three-Dimensional Culture of Vascularized Thermogenic Adipose Tissue from Microvascular Fragments
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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
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科学领域:

  • 内分泌学 在内分泌学.
  • 代谢过程中的代谢.
  • 人体生理学 人体生理学

背景情况:

  • 宪法性瘦身,一个生理学上确定的体重不足状态,出现在20世纪初的科学文献中.
  • 它呈现出一个悖论:一个健康的个体与正常摄入抵制体重增加,与神经性厌食症不同.
  • 尽管它具有引人入胜的性质,但与肥胖研究相比,对宪法瘦身的研究是有限的.

研究的目的:

  • 审查当前关于体型薄弱的证据,涵盖其定义,诊断和潜在机制.
  • 探索这种持久的薄型表型的代谢和生理方面.
  • 突出研究体质薄弱的潜力,以了解能量平衡和识别肥胖保护因素.

主要方法:

  • 本综述综合了关于体内瘦身的现有科学文献.
  • 它检查了临床研究,代谢研究和生理学研究.
  • 重点是与定义,诊断和机制相关的证据.

主要成果:

  • 宪法性瘦身的特点是持续体重不足的健康状态,可以抵抗体重增加.
  • 这种类型的代谢和生理机制是复杂的,并未完全理解.
  • 有限的研究存在,阻碍了全面的理解和临床认可.

结论:

  • 对于医学和社会认可而言,对体型薄弱的进一步研究至关重要.
  • 了解它的机制可以为能量平衡和新陈代谢提供宝贵的见解.
  • 从体型瘦身的洞察力可以提供与全球肥胖大流行相关的保护性代谢模式.