与黑色素瘤患者免疫治疗相关的皮肤免疫相关不良事件
Journal of drugs in dermatology : JDD
|May 6, 2025
概括
皮肤免疫相关的不良事件 (irCAE) 在黑色素瘤免疫疗法中很常见. 进步治疗irCAE的患者更有可能经历全身副作用.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 与皮肤免疫相关的不良事件 (irCAE) 经常与用于晚期黑色素瘤治疗的免疫检查点抑制剂 (ICI) 观察到.
- 了解皮肤和全身IRAEs之间的关系对于治疗免疫疗法患者的管理至关重要.
研究的目的:
- 在接受ICI的黑色素瘤患者中比较系统性irAEs的发生率,有或没有并发的irCAEs.
- 在黑色素瘤的不同治疗环境中,研究皮肤和全身IRAE之间的关联.
主要方法:
- 追溯队列研究涉及147名黑色素瘤患者,他们在莫菲特癌症中心接受ICI治疗.
- 在接受辅助和二线ICI治疗的患者中分析irCAE和全身irAE发生情况.
- 群体间IRAE的统计比较和整体存活率的评估.
主要成果:
- 在辅助性ICI组中,38.8%的患者经历了irCAE,54.4%的患者也经历了系统性irAE,尽管并没有显著的相关性 (P=0.240).
- 在第一线ICI进展的转移组中,28.8%的患者在二线治疗中经历了irCAE,其中53.3%的人也患有系统性irAE,显示出显著的关联 (P<0.001).
- 患有IrCAE的患者 (118个月) 与没有IrCAE的患者 (69个月) 的平均整体存活时间较长,尽管在统计学上不显著 (P=0.102).
结论:
- 患有III/IV阶段黑色素瘤的患者在一线ICI上进展,并患有irCAE,他们更有可能也患有系统性irAE.
- 皮肤和全身IRAE之间的关联在转移环境中是显著的,但在辅助环境中没有.
- 进一步的研究可能会澄清irCAE在接受免疫治疗的黑色素瘤患者的预后影响.
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