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针对高级基底细胞癌的刺抑制剂的有效性和安全性:专家共识小组的专家共识小组

Joshua Burshtein, Milaan Shah, Danny Zakria

Journal of drugs in dermatology : JDD

|May 6, 2025

概括

像sonidegib和vismodegib这样的刺抑制剂 (HHI) 在手术或放射治疗不可行时,为高级基底细胞癌 (laBCC) 提供治疗选择. 这种专家的共识指导了它们的使用,并管理了常见的副作用,如肌肉和脱发.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学

背景情况:

局部发达的基底细胞癌 (laBCC) 提出了治疗挑战,特别是对于那些不适合手术或放射治疗的患者.
刺抑制剂 (HHI) 代表了laBCC的治疗进步,为无法切除或复发的疾病提供了替代方案.

研究的目的:

建立专家共识的指导方针,以优化对刺抑制剂 (HHI) 在管理laBCC.管理中的使用.
为临床决策提供信息,并加强laBCC.患者的患者护理策略.

主要方法:

一个系统的文献搜索发现了有关基底细胞癌的HHIs的相关研究.
一个由皮肤科医生组成的专家小组召开会议,审查证据并制定共识陈述.
修改后的Delphi过程被采用,以达成共识,并分配强度的建议.

主要成果:

专家小组一致通过了八项共识声明和建议.
根据证据的不同强度 (A,B和C) 将建议分类.

结论:

索尼迪基布和维斯莫迪基布是FDA批准的高血压抑制剂,有效降低laBCC瘤大小,用于新辅助疗法或作为初级治疗.
与HHIs相关的常见不良事件包括肌肉,脱发症和失味症 (味道变化).

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