在患有严重烧伤的儿科患者中,C-反应性蛋白-白蛋白比率和预后之间的关系

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Updated: May 12, 2025

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Serap Samut Bülbül¹, Alper Ceylan², Metin Ocak³

¹Faculty of Medicine, Department of Pediatric Surgery, Samsun University, Samsun, Turkey.

PloS one

|May 6, 2025

概括

在严重烧伤的儿童中,入院时高C反应蛋白 (CRP) 与白蛋白的比率表明住院时间较长. 这个比率可以帮助预测儿科烧伤患者的停留时间 (LOS).

科学领域:

生物化学生物化学
临床医学临床医学
儿科儿科儿科

背景情况:

C-反应蛋白 (CRP) 是一种关键的急性相反应剂.
专蛋白水平可能会受到严重疾病和伤害的影响.
CRP-白蛋白比率可以提供对患者预后的见解.

研究的目的:

检查专蛋白,CRP和CRP-专蛋白比率与儿科重度烧伤患者住院时间 (LOS) 的相关性.
为了确定这些生物标志物是否可以预测该人口中的LOS.

主要方法:

对150名患有三度和四度烧伤的儿科患者的回顾性分析.
在2019年1月至2023年9月期间收集的数据.
统计分析以将生物标志物水平 (白蛋白,CRP,CRP-白蛋白比率) 与医院LOS相关联.

主要成果:

与停留时间较长 (p < 0.001) 的患者相比,在LOS ≤10天的患者中观察到显著较低的平均CRP-专蛋白比率.
患有21-30天和>40天的LOS的患者表现出显著更高的CRP-专蛋白比率 (p < 0.001).
医院LOS与CRP-白蛋白比率显著正相关 (p < 0.001; r = 0.529).

结论:

在入院时低白蛋白,高CRP和升高的CRP-白蛋白比率可能与儿科严重烧伤患者的临床表现相关.
红蛋白-白蛋白比率是严重烧伤儿童住院时间的重要预测指标.
这些发现表明,CRP-白蛋白比率在儿童烧伤患者的管理和预测结果方面具有实用性.

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