多种微量元素与青少年双相情感障碍的关联:一个病例对照研究
Jie Li1,2, Xuemei Li1,2, Yuqian He1,2
1Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
PloS one
|May 6, 2025
概括
尿液中的微量元素含量与青少年双相情感障碍 (BD) 有关. ,和的较低水平,和的较高水平与青少年的BD有关.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 生物化学 生物化学
背景情况:
- 双极性障碍 (BD) 是一个重要的心理健康状况.
- 以前的研究表明,微量元素和精神障碍之间存在联系.
- 微量元素和青少年BD之间的关联需要进一步调查.
研究的目的:
- 调查多种微量元素与青少年双相情感障碍 (BD) 之间的联系.
主要方法:
- 一项病例控制研究涉及144名青少年BD患者和144名匹配的对照.
- 通过诱导合血质谱法 (ICP-MS) 量化了17个尿元素.
- 统计分析包括LASSO,后勤回归,RCS和BKMR来评估元素-BD关联.
主要成果:
- 尿中的,和与青少年BD的负相关性.
- 尿中的和与青少年BD呈现正相关性.
- 观察到,,,,,,,,和的非线性关联; BKMR表明了元素的联合作用.
结论:
- 尿中的,和水平与青少年BD负相关.
- 尿中的和水平与青少年BD有积极的相关性.
- 这些发现支持尿道微量元素和青少年BD之间的显著联系.
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