农药暴露引起的微生物乱及其对妊娠期糖尿病的预测影响
Xu Yang1,2,3, Yuqing Zhang4, Yifan Xu1,2
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, Nanjing Medical University, Nanjing 211166, China.
Environmental science & technology
|May 6, 2025
概括
母亲接触农药和肠道微生物组的变化增加了妊娠期糖尿病 (GDM) 的风险. 一项研究发现,特定的微生物模式和农药水平可以预测GDM,提供预防的目标.
科学领域:
- 环境健康 环境健康
- 微生物组研究 微生物组研究
- 生殖内分泌学 生殖内分泌学
背景情况:
- 农药暴露和肠道微生物组的改变与妊娠期糖尿病 (GDM) 风险有关.
- 了解环境因素和GDM中的微生物群之间的相互作用至关重要.
研究的目的:
- 调查农药暴露和肠道微生物群对GDM风险的相互作用影响.
- 确定用于预测GDM发展的生物标志物.
- 探索肠道微生物组在农药诱导的GDM中扮演的调解角色.
主要方法:
- 分析了852名孕妇的血清杀虫剂含量和肠道微生物群 (16S rRNA和中枪转基因组学).
- 探索农药暴露和微生物组成之间的相互作用.
- 使用已识别的生物标志物的预测模型的开发.
主要成果:
- 农药混合物的环境风险评分 (ERS) 与GDM有关.
- 肠道微生物群,特别是多雷亚分支,调解了农药和GDM之间的关系.
- 低Prevotella丰富度和高ERS的组合显著增加了GDM风险 (10.36倍).
- 识别的生物标志物实现了高GDM预测准确度 (AUC:0.833).
结论:
- 孕产妇接触农药可以破坏微生物群,导致血糖变化和增加GDM风险.
- 研究结果表明,GDM是治疗干预和预防策略的潜在生物标志物.
- 需要进一步进行临床评估,以了解农药诱导的微生物组依赖的糖质变化的影响.
相关概念视频
Pathophysiology of Diabetes
837
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
837
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Diabetes Mellitus: Overview and Type I Subtype
2.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
Diabetes: Symptoms, Diagnosis, and Complications
494
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
494
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K
Overview of Carbohydrate Metabolism
630
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
630


