DNA 基甲基酶 Tet1 和 Tet2 通过 IGF-1/mTOR 信号轴调节骨老化和 BMSC 代谢

Nicholas Smith1,2, Dimitrios Cakouros1,2, Feargal J Ryan1,3

  • 1School of Biomedicine, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia.

PubMed
概括

十-十一转位 (Tet) 1和2通过支持骨髓细胞 (BMSC) 功能来调节骨发育. 它们的放松调节加速了与年龄相关的骨质流失和过早衰老,特别是在男性身上.

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