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现代工业化饮食摄入对等离子体蛋白质组的影响

Melinda Solomon¹, Mahyar Heydarpour², Laura C Tsai²

¹Section of Nephrology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA.

American journal of hypertension

|May 6, 2025

概括

与祖先的饮食相比,高饮食增加纤维化蛋白质,减少免疫蛋白质. 这种血蛋白质组转移可能导致心血管疾病和高血压.

科学领域:

心血管科学心血管科学
蛋白质组学是指蛋白质组学.
人体生理学人体生理学

背景情况:

饮食中高摄入量是心血管疾病的已知危险因素.
不同摄入量对等离子体蛋白质组的影响尚不完全理解.

研究的目的:

研究控制饮食干预对正常血压个体等离子体蛋白质组的影响.
为了比较限制 (类似于祖先) 和充 (现代工业化) 饮食之间的蛋白质变化.

主要方法:

一项前性研究,涉及两次饮食干预的正常压力参与者.
在限制 (约230毫克/天) 和充 (约4600毫克/天) 的饮食后,对1512种蛋白质进行蛋白质组分析.
评估24小时尿液中的分泌量,以确认饮食遵守.

主要成果:

负荷显著增加了与纤维化和细胞外基质 (ECM) 重塑相关的蛋白质.
限制增加了参与免疫/炎症途径的蛋白质和氨酸-血管素系统 (RAS) - 氨酸-氨酸系统 (KKS).
像NT-proBNP,原蛋白和TGF-β RIII这样的特定蛋白质在高的情况下增加,而雷宁,血和阿波利波蛋白A-1在低的情况下增加.

结论:

现代工业化高饮食改变了血蛋白质组,促进纤维化和ECM蛋白,同时抑制免疫和RAS/KKS通路.
这些蛋白质组变化提供了对与相关的高血压和心血管疾病背后的机制的见解.
这项研究提供了一个全面的蛋白质学图谱,介绍了饮食中的对正常压力个体的影响.

关键词:

血压血压血压血压纤维化纤维化这种高血压,高血压.蛋白质组是蛋白质组的组成部分.酸盐的使用方法

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