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Updated: May 9, 2025

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在miR-208a前的罕见DCM相关变异破坏了miRNA成熟和功能

Yolan J Reckman1, Jan Haas2, Ingeborg van der Made1

  • 1Amsterdam UMC, University of Amsterdam, Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Human molecular genetics
|May 6, 2025
PubMed
概括

在miR-208a前体分子中的遗传变异与扩张性心肌病 (DCM) 有关. 这些特定变异会损害成熟的miR-208a的产生和功能,可能导致心力衰竭的发展.

关键词:
扩展性心肌病变性是指扩展性心肌病变性.罕见的功能变体罕见的功能变体.在 miR-208a 中,这是一个微型RNA.

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