对盐水和乳酸溶液作为红细胞输血洗溶液的影响进行比较研究
Xiaomin Su1, Xin Liu2, Guoquan Zhang1
1Shaanxi Province Blood Center, Institute of Xi'an Blood Bank, 407# Zhuque Ave, Xi'an, Shaanxi Province 710061, China.
概括
用乳酸环球溶液 (LRS) 清洗红细胞 (RBC) 在减少储存损伤方面表现优于盐水. 这两种解决方案都对输血安全有效,而LRS在红细胞质量保护方面提供了特定的优势.
科学领域:
- 血液银行和输血医疗服务
- 蛋白质学和代谢学.
- 红细胞储存的生物化学
背景情况:
- 红细胞 (RBC) 储存与生化和结构变化有关,称为储存损伤.
- 洗净红细胞是缓解这些储存病变的一种方法.
- 对比不同的洗溶液对于优化红细胞保存至关重要.
研究的目的:
- 为了比较用盐水洗净的红细胞的质量,蛋白质学和代谢学,与乳酸环球溶液 (LRS) 相比.
- 评估洗溶液对5周内红细胞储存病变发展的影响.
- 为了确定与不同的洗溶液相关的蛋白质和代谢变化.
主要方法:
- 红细胞单位被分为对照组 (未冲洗),用盐水冲洗和用LRS冲洗.
- 样品存储了5周,在多个时间点进行评估.
- 储存后进行了蛋白质组和非向代谢组分析.
主要成果:
- 所有洗过的红细胞都符合国家标准;洗过的红细胞的Na+,K+,葡萄糖,LDH和2,3-DPG比未洗过的更低.
- 低血压和盐水洗减少了红细胞储存病变.
- 蛋白质组和代谢组分析显示,每个洗组的特定途径发生了明显的变化.
结论:
- 与盐水相比,乳酸溶液 (LRS) 在某些方面在红细胞保存方面表现优越.
- 盐水和LRS都是红细胞的安全有效的洗溶液.
- 综合的奥米克分析提供了对红细胞储存损伤调节背后的机制的见解.
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