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个人暴露于颗粒物氧化潜力和呼吸道炎症:喘和非喘成年人之间的差异
Miguel Santibáñez1, Juan José Ruiz-Cubillán2, Juan Agüero2
1Global Health Research Group, Dpto Enfermería, Faculty of Nursing, Universidad de Cantabria-IDIVAL, Avda. Valdecilla, s/n, 39008, Santander, Spain.
概括
暴露于颗粒物氧化潜力 (PM-OP) 与呼吸道炎症有关. 非喘患者在PM-OP和增加的微分呼出氧化 (FeNO) 水平之间表现出更强烈的关联,这表明喘患者具有保护作用.
科学领域:
- 环境健康 环境健康
- 呼吸系统医学 呼吸系统医学
- 毒理学 毒理学 毒理学
背景情况:
- 暴露于颗粒物 (PM) 是呼吸系统疾病的已知危险因素.
- 氧化潜力 (OP) 是颗粒物的生物活性标志物.
- 呼吸道炎症,以分数呼出的氧化 (FeNO) 为标志,是喘的一个关键特征.
研究的目的:
- 调查个人暴露在PM氧化潜力 (PM-OP) 和呼吸道炎症 (FeNO) 之间的关联.
- 为了比较喘患者和非喘志愿者的这些关联.
主要方法:
- 42名喘患者和37名对照者佩戴24小时PM2.5和PM10-2.5采集的个人样本.
- 通过dithiothreitol (DTT) 和ascorbic acid (AA) 的测定来测量PM-OP.
- 暴露后24小时测量了部分呼出的氧化 (FeNO).
- 进行了为混因素调整的统计分析 (aMDs,aORs).
主要成果:
- 在非喘志愿者中观察到PM-OP和FeNO之间的显著关联 (例如,OP-DTT PM2.5的aMD=11.64ppbs,OP-AA PM10-2.5的aOR=18.18).
- 喘患者的相关性是较低的 (aORs = 1.91 和 1.94).
- 在非喘患者中,在微小部分的OP-AA中观察到更高的FeNO水平,但不显著 (aMD = 5.22,aOR = 3.92).
结论:
- 在喘患者和非喘患者之间,个人暴露于PM-OP与呼吸道炎症有着不同的关联.
- 非喘患者中较高的关联表明,吸入的皮质类固醇可能会降低喘患者的呼吸道上皮质反应性.
- PM-OP是评估呼吸道炎症风险的相关暴露标志物.
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