记忆检索过程中大脑激活的改变调解了发育创伤和精神病症状严重程度之间的关系
Ava J C Mason1, William Palmer2, Hengyi Cao3
1Division of Psychiatry, University College London, UK.
Schizophrenia research
|May 6, 2025
概括
发育性创伤 (DT) 与精神病风险有关. 情节性记忆表现和大脑活动,特别是在下叶,可能会在有风险的年轻人中调解这种联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 发育性创伤 (DT) 与精神病症状的风险增加有关.
- 连接DT与精神病的确切机制,特别是关于记忆的机制,尚未完全理解.
研究的目的:
- 调查记忆检索期间的情节性记忆表现和大脑活动是否调解了创伤多重性和青少年精神病风险症状之间的关系.
- 在关联记忆任务期间,探索fMRI活动在与记忆相关的区域中的作用.
主要方法:
- 分析了北美Prodrome长度研究 (第二阶段) 795名参与者的数据.
- 发展创伤,神经认知表现和精神病风险症状的评估.
- 在对联记忆任务 (n=198) 中,从一个子样本 (n=219) 的fMRI数据中使用线性和调解分析进行了分析.
主要成果:
- 在五个与记忆相关的区域中的平均功能激活介导了DT和亚临床幻觉/妄想严重程度之间的关联的7-9%.
- 下侧顶叶活动特别介导了8.7-10%的DT和亚临床幻觉/妄想严重程度之间的关联.
结论:
- 情节性记忆处理和下叶激活在发育创伤和精神病之间的关联中发挥着作用.
- 这些发现提供了对创伤暴露的年轻人精神病风险背后的机制的见解,并可能具有临床意义.
更多相关视频
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.1K
09:55Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
Published on: March 8, 2018
12.4K
相关概念视频
Traumatic Memory
82
Emotionally traumatic events often lead to memories that are exceptionally vivid and enduring, sometimes persisting with remarkable clarity throughout an individual's life. A classic example of this phenomenon is a person who survives a car accident. Even years later, they may recall every detail of the event with startling accuracy — the screeching of the tires, the jarring impact, and the acrid smell of burning rubber. Such vividness contrasts sharply with how an individual...
82
Post-traumatic Stress Disorder
30
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
30
Dissociative Disorders
46
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
46
Repressed Memory
73
Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
73
Psychological and Sociocultural Causes of Schizophrenia
81
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
81
