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Ayushe A Sharma¹, Jane B Allendorfer², Stephen Correia³

¹Departments of Neurology University of Alabama at Birmingham (UAB), Birmingham, AL, USA.

NeuroImage. Clinical

|May 6, 2025

概括

神经行为疗法 (NBT) 改善了功能性 (FS) 和创伤性脑损伤 (TBI) 患者的功能神经症状和大脑结构. NBT导致左叶灰质体积增加,与功能改善相关.

科学领域:

神经科学是一个神经科学.
神经学神经学
精神病学是一个精神病学.

背景情况:

功能神经学症状障碍,包括功能性 (FS),是普遍存在的,使人衰弱的.
神经行为疗法 (NBT) 在减少和改善FS的心理症状方面表现有前途,但其神经生物学基础尚未得到充分理解.

研究的目的:

研究NBT对创伤性脑损伤和功能性发作 (TBI-FS) 患者的大脑结构的神经生物学影响.
检查与NBT相关的灰质体积 (GMV) 的变化及其与临床改善的相关性.

主要方法:

结构磁共振成像 (MRI) 用于比较健康成年人,仅TBI患者和TBI-FS患者在NBT前后的GMV变化.
基于voxel的形态测量和voxelwise重复测量的ANOVA被用于分析MRI数据.

主要成果:

接受NBT的TBI-FS参与者在左下和中旋中显示GMV显著增加.
NBT治疗与发作频率的显著减少以及抑郁和焦虑症状的改善有关.
增加的左側時性GMV與改善的整體心理,社會和職業功能有正面關聯.

结论:

在TBI-FS患者中,NBT诱导左叶的结构性大脑变化,这与功能和心理改善有关.
这项研究强调了NBT在促进大脑可塑性的潜力,并提出了功能神经障碍未来治疗干预的目标.

关键词:

离散性发作离散性发作功能性发作功能性发作灰色物质的体积,灰色物质的体积.神经行为疗法是一种神经行为疗法.神经形态测量是一种神经形态测量.精神引起的非发作.创伤性脑损伤是一种创伤性脑损伤.

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