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Updated: May 9, 2026

Constant Pressure-controlled Extrusion Method for the Preparation of Nano-sized Lipid Vesicles
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在通过交叉流过的脂质纳米颗粒净化过程中,依赖时间的颗粒大小增加

Annabelle Dietrich1, Nicole Beckert1, Jürgen Hubbuch1

  • 1Karlsruhe Institute of Technology (KIT), Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Fritz-Haber-Weg 2, Karlsruhe, 76131, Germany.

Journal of colloid and interface science
|May 6, 2025
PubMed
概括

交叉流过 (CFF) 为净化脂质纳米颗粒 (LNP) 提供了一种有效的方法,保持其特性并实现高回收率. 这种可扩展的净化技术显示了未来LNP生产和储存的前景.

关键词:
在线监控在线监控交叉流过的过方法透析是通过透析进行的.脂质纳米颗粒是一种纳米粒子.粒子聚变是指粒子的聚变.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...