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Updated: May 9, 2025

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通过抑制PARP,通过增强瘤中的HLA-G表达,引起NK细胞相关的免疫逃避

Siyuan Wang1, Yu Xia2, Yiyu Qian2

  • 1Cancer Biology Research Center (Key Laboratory of Chinese Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan 430030, China; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
|May 6, 2025
PubMed
概括

聚 ((ADP-ribose) 聚合酶抑制剂 (PARPi) 增加了自然杀手 (NK) 细胞的透,但也提高了免疫检查点HLA-G的调节. 将PARPi与HLA-G阻断相结合,可以增强NK细胞抗瘤活性和抑制瘤生长.

关键词:
在 HLA-G 的情况下.在 NK 细胞中,NK 细胞是 NK 细胞.在 PARP 抑制剂.美国联邦税务法 (TFEB)瘤的免疫规避是瘤的免疫规避.

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