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Updated: Apr 30, 2026

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples
09:45

Method for Measuring the Activity of Deubiquitinating Enzymes in Cell Lines and Tissue Samples

Published on: May 10, 2015

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综合性近接-ubiquitomics 概况为 deubiquitinase 基底的发现应用到 USP3030 的应用

Andreas Damianou1, Hannah B L Jones2, Athina Grigoriou2

  • 1Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, OX3 7FZ Oxford, UK; Chinese Academy for Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, OX3 7FZ Oxford, UK.

Cell chemical biology
|May 6, 2025
PubMed
概括

研究人员开发了一种新方法,以找到直接二维基因酶 (DUB) 基质. 这种技术确定了USP30目标,包括LETM1,揭示了对疾病中的DUBs的新见解.

关键词:
在APEX2中,APEX2是APEX2的第二个版本.在LETM1中,LETM1是LETM1.美国人民币30美元没有二维基因酸酶.质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量蛋白质组学 蛋白质组学邻近-无处不在的图形学.接近性标签的标签.无处不在的特异性蛋白酶30

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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