Jove
Visualize
联系我们

相关概念视频

General Transcription Factors01:30

General Transcription Factors

5.1K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.1K
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

15.1K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
15.1K
Transcription Factors02:16

Transcription Factors

75.5K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
75.5K
Position-effect Variegation02:32

Position-effect Variegation

6.3K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.3K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

23.2K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
23.2K
Gene-Environment Interactions01:20

Gene-Environment Interactions

226
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
226

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<i>Trans</i>-eQTL hotspots shape complex traits by modulating cellular states.

bioRxiv : the preprint server for biology·2023
Same author

Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation.

eLife·2022
Same author

Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation.

eLife·2020
Same author

Systematic identification of <i>cis</i>-regulatory variants that cause gene expression differences in a yeast cross.

eLife·2020
Same author

Genetics of <i>trans</i>-regulatory variation in gene expression.

eLife·2018
Same author

Towards combinatorial transcriptional engineering.

Biotechnology advances·2017
Same journal

The Single-Cell Pediatric Cancer Atlas: Data portal and open-source tools for single-cell transcriptomics of pediatric tumors.

Cell genomics·2026
Same journal

NERINE reveals rare variant associations in gene networks across phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease.

Cell genomics·2026
Same journal

Single-cell profiling of DNA methylation in autism spectrum disorder prefrontal cortex reveals distinct regulatory and aging signatures.

Cell genomics·2026
Same journal

BMI-genome interactions regulate global gene expression with emphasis in brain and gut.

Cell genomics·2026
Same journal

Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.

Cell genomics·2026
Same journal

CellBouncer, a unified toolkit for single-cell demultiplexing and ambient RNA analysis, reveals hominid mitochondrial incompatibilities.

Cell genomics·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: May 17, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.5K

跨eQTL热点通过调节细胞状态来塑造复杂的特征.

Kaushik Renganaath1, Frank Wolfgang Albert1

  • 1Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.

Cell genomics
|May 6, 2025
PubMed
概括
此摘要是机器生成的。

影响基因表达的遗传变异显著影响复杂的特征. 跨作用调节热点,而不是局部变异,是这些连接和酵母菌生长变化的关键驱动因素.

关键词:
QTLs 是一个 QTL.复杂的特征是复杂的特征.表示 QTLs QTLs.基因表达的基因表达方式遗传变异是一种遗传变异.遗传性 遗传性 遗传性调解 调解 是一种调解方式.类型的类型.定量遗传学定量遗传学酵母酵母是一种酵母.

更多相关视频

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.1K
HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.2K

相关实验视频

Last Updated: May 17, 2025

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.5K
Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.1K
HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.2K

科学领域:

  • 遗传学 是一个遗传学.
  • 系统生物学 系统生物学
  • 酵母遗传学 酵母遗传学

背景情况:

  • 调节性遗传变异影响基因表达,将DNA变异与复杂的特征联系起来.
  • 了解基因表达和复杂特征之间的因果关系至关重要,但具有挑战性.

研究的目的:

  • 研究Saccharomyces cerevisiae中的基因表达和复杂生长特征的遗传基础.
  • 确定将基因表达与表型变异联系起来的调节机制.

主要方法:

  • 从酵母杂交中整合了转录基因数据与46个复杂的生长特征.
  • 分析基因表达和生长特征之间的遗传相关性.
  • 确定监管位置,包括跨作用热点.

主要成果:

  • 在基因表达和酵母菌生长之间发现了成千上万的遗传相关性.
  • 跨作用调节点,特别是热点,是遗传相关性和生长变异的主要贡献者.
  • 当地的监管变化起到了很小的作用.

结论:

  • 跨作用调节热点通过调节细胞状态来显著塑造复杂的特征.
  • 由转基因作用因子驱动的基因表达变化对于复杂的特征变异至关重要.