[治疗细菌内心炎的罕见副作用]
Carola Andrea George1, Fabian Gisler2, Ursula Flückiger1
1Zentrum für Innere Medizin, Hirslanden Klinik Aarau, Aarau, Schweiz.
Deutsche medizinische Wochenschrift (1946)
|May 6, 2025
概括
对内心炎的阿莫西西林治疗导致损伤和结石形成. 在长时间的阿莫西西林治疗期间,特别是高剂量治疗时,定期监测功能至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺内心炎需要有效的抗微生物治疗.
- 氨基是一种常见的抗生素,但需要考虑潜在的脏副作用.
- 急性损伤 (AKI) 可以使治疗复杂化,并需要调整治疗.
研究的目的:
- 报告一种罕见的阿莫西西林诱导的尿病病例.
- 强调长期阿莫西西林治疗期间对功能监测的重要性.
- 讨论水晶病作为阿莫西西林的潜在不良影响.
主要方法:
- 病例报告详细介绍了一名被诊断患有Enterococcus faecalis内心炎的患者.
- 抗微生物治疗的文件,包括阿莫西西林和 gentamicin,随后由于AKI转换为 ceftriaxone.
- 对诊断结果的分析,包括心声回声,血液培养,尿液分析,腹部CT和石头分析.
主要成果:
- 患者患有阿莫西西林诱导的尿病,其结石完全由阿莫西西林组成.
- 结石导致阻塞性脏病,由水和AKI表示.
- 在阿莫西西林调整和停止后,功能正常化,两年后内心炎没有复发.
结论:
- 氨基可以引起水晶病和尿病,这是一个罕见但严重的副作用.
- 在高剂量,长时间的阿莫西西林治疗期间,密切监测功能至关重要.
- 快速识别和管理阿莫西西林诱导的脏病对于患者的治疗结果至关重要.
相关概念视频
Combined Effects of Drugs: Synergism
3.6K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.6K
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
409
Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
409
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
103
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
103
Heart Failure Drugs: Inotropic Agents
445
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
445
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
331
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
331
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
719
Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
719


