在研究大规模网络变化的大脑功能连接在双相情感障碍的个体之间的进展
Siyu Sun1, Siqi Wang2, Yujun Gao3
1Department of psychiatry, Binzhou Medical University Hospital, Binzhou, Shandong Province, 256600, China; Binzhou Medical University, Binzhou, Shandong Province, 256600, China; Department of Psychiatry, Wuhan Wuchang Hospital, Wuhan University of Science and Technology, Wuhan 430063, China.
Neuroscience
|May 6, 2025
概括
双极性障碍 (BD) 破坏了大脑网络连接,特别是在默认模式,突出和中央执行网络中. 关键的大脑区域,如后带状皮质对于BD诊断和评估认知缺陷至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 双极性障碍 (BD) 涉及结构性和功能性大脑损伤.
- 之前关于BD中的功能连接 (FC) 的研究显示了不一致的结果.
- 需要进行大规模的网络分析才能全面了解BD.
研究的目的:
- 系统地审查功能磁共振成像 (fMRI) 关于双相情感障碍中大脑网络变化的研究.
- 了解BD患者主要大脑网络内部和之间功能连接 (FC) 的变化.
主要方法:
- 在PubMed和Web of Science中使用"双极性障碍"",大脑网络"和"功能连接"等关键词进行系统的文献搜索.
- 包括使用功能磁共振成像 (fMRI) 来评估FC的研究.
- 分析了51项选定的研究.
主要成果:
- 在休息的BD患者中,在默认模式网络 (DMN),突出网络 (SAN) 和中央执行网络 (CEN) 中观察到减少的内在连接.
- 还确定了其他大脑网络的变化.
- 这些变化表明BD中与情绪和认知功能相关的复杂连接模式.
结论:
- 双极性障碍 (BD) 在休息和任务状态期间显著破坏大脑网络活动.
- 特定的区域,包括后带状皮质 (PCC),前带岛 (AI),后中心 (PoCG) 和前 (PreCu),对于BD识别,诊断和认知缺陷评估至关重要.
- 需要进一步的研究,以探索其他潜在的相关网络在BD.
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