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在接受重大选择性手术的高风险患者中,针对大脑的目标导向疗法:BRAIN-PROMISE随机试验的研究协议

Massimiliano Greco¹, Giulio Calgaro¹, Mattia Cavallo²

¹Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Department of Anesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Contemporary clinical trials

|May 6, 2025

概括

这项研究研究近红外光谱学 (NIRS) 以引导麻醉和减少老年手术患者的并发症. 针对NIRS的向治疗显示出改善高风险个体的结果的希望.

科学领域:

麻醉学和外科手术期间的医学.
老年人手术是一门老年人手术.
神经临界护理是指神经临界护理.

背景情况:

老年人和虚弱的患者面临术后并发症的风险增加,包括认知功能障碍和妄想.
麻醉管理和血液动力学监测对于这些脆弱人群的长期结果至关重要.
近红外光谱 (NIRS) 测量区域大脑氧和 (rSO2),可能识别早期组织缺氧.

研究的目的:

评估NIRS向的目标导向疗法是否能降低高风险老年手术患者的rSO2滴.
评估NIRS指导治疗对术后并发症和长期结果的影响.

主要方法:

一项前性随机对照试验,招募年龄≥65岁或脆弱性评分≥5的患者接受重大手术.
随机化为NIRS向的管理或标准护理,在实验组中NIRS指导干预.
主要结局:经过30天的术后并发症. 二次结局:认知功能障碍,妄想,停留时间长,90天死亡率.

主要成果:

这个部分不在所提供的摘要中.
需要进一步的研究来证实这些发现.

结论:

这项研究探讨了一种使用NIRS向目标导向疗法的创新方法.
这些发现表明,在全身麻醉下,在高风险的老年患者中,有改善术后结果的潜力.

关键词:

复杂性复杂性复杂性流体流体流体流体脆弱性脆弱性脆弱性血液动力学监测血液动力学监测护士们的护士们手术手术手术术术

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