皮质连接体梯度的功能障碍和恢复及其与甲基胺和海洛因使用障碍中的基因表达特征的关联
Zhe Du1, Wenhan Yang2, Xinwen Wen1
1School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, China.
概括
大脑中的功能连接体梯度 (FCG) 显示了戒断后物质使用障碍 (SUD) 的功能障碍和恢复. 这些FCG变化可能预测渴望减少,为SUD治疗提供潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 遗传学 遗传学是一种遗传学.
背景情况:
- 药物使用障碍 (SUD) 与大脑网络组织的破坏有关.
- 功能连接体梯度 (FCG) 标志着大脑网络层次结构,但它们在SUD中的变化和恢复尚未得到充分理解.
- 在SUDs中FCG变化的遗传基础在很大程度上仍未被探索.
研究的目的:
- 在长期戒断后,研究甲基胺使用障碍 (MUD) 和海洛因使用障碍 (HUD) 患者的皮质FCG功能障碍和恢复.
- 探索腹膜区域 (VTA) 谷氨酸水平和皮质FCG之间的关系.
- 使用FCG检查FCG变化的遗传基础,并预测使用FCG的渴望变化.
主要方法:
- 利用了三个独立的数据集 (n=247),包括MUD (n=131) 和HUD (n=36) 队列.
- 采用磁共振光谱 (MRS) 来测量VTA谷氨酸和死后基因表达,用于转录造型.
- 开发了基于基线皮质FCG的支持向量回归 (SVR) 模型,以预测渴望变化.
主要成果:
- 患有MUD和HUD的个体在关键大脑网络 (DAN,VAN,FPN,DMN) 中表现出类似的皮质FCG功能障碍和恢复模式.
- VTA的谷氨酸水平与前端双网络 (FPN) 和边缘网络 (LIM) 之间的梯度距离相关.
- 转录特征,特别是与突触信号相关的特征,解释了改变的FCG模式;基线FCG预测了随后的渴望减少.
结论:
- 皮质FCG的改变为SUD作为可治疗的疾病提供了洞察力.
- 在SUDs中,FCG变化表明长期戒断后的恢复潜力.
- 皮质FCG可以作为潜在的生物标志物来预测SUD患者的渴望变化.
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