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Updated: May 9, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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布普伦诺芬的结构性决定因素 在μ-阿片类受体的部分激素作用

Antoniel A S Gomes1,2,3, Jesús Giraldo1,2,3

  • 1Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.

Journal of chemical information and modeling
|May 6, 2025
PubMed
概括

布普伦诺芬是一种更安全的止痛替代品,具有独特的微型阿片类受体 (microOR) 相互作用. 这些结构上的差异解释了它的部分激应和偏向信号,为新型止痛药设计铺平了道路.

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