来自KOBIO注册表的老年患者中难以治疗的类风湿性关节炎
Ju-Yang Jung1, Eunyoung Lee2, Ji-Won Kim1
1Department of Rheumatology, Ajou University School of Medicine, Suwon, Republic of Korea.
European journal of internal medicine
|May 6, 2025
概括
难以治疗的类风湿性关节炎 (D2T-RA) 影响10.5%的生物/向合成DMARDs的老年患者. 在这个人群中,非药物存活率,而是无效率驱动D2T-RA,需要量身定制的治疗策略.
科学领域:
- 类风湿病学 类风湿病学
- 临床免疫学临床免疫学
- 老年医学 老年医学
背景情况:
- 难以治疗的 (D2T) 类风湿性关节炎 (RA) 被定义为治疗失败,尽管有多个生物或有针对性的合成疾病修饰性抗风湿药物 (b/tsDMARD) 循环.
- 老年RA患者往往呈现出增加的疾病活性和并发症,使管理复杂化.
研究的目的:
- 确定在接受b/tsDMARDs的老年RA患者中D2T-RA的流行率.
- 在这个人口群体中调查与D2T-RA相关的特征和治疗结果.
主要方法:
- 从韩国风湿病学学院生物药物注册表提取回顾性数据.
- 对65岁及以上接受b/tsDMARD治疗的RA患者的分析.
主要成果:
- 在516名老年RA患者中,10.5%的患者表现出D2T-RA.
- 与D2T-RA相关的因素包括年轻的年龄,较高的RAPID3得分,以及之前没有使用勒诺米德或多重常规合成DMARD (csDMARD).
- 虽然药物存活率相似,但在D2T-RA组中,无效是更常见的退出原因,在1年和2年的随访中,D2T-RA组也持续显示出更高的疾病活性.
结论:
- 在接受b/tsDMARDs的老年RA患者中,D2T-RA占10.5%的患病率.
- 特定因素,如年轻的年龄和先前的药物 anamnesis 与D2T-RA相关.
- 在D2T-RA中持续的疾病活动强调了持续的疗效评估和个性化治疗方法的必要性,以实现最佳的类风湿性关节炎管理.
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