转移性细胞癌的管理:指南更新
Regina Barragan-Carrillo1, Anna Scavuzzo2, Miguel Angel Jimenez-Rios2
1Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA; Department of Medical Oncology, Instituto Nacional de Cancerologia, Mexico City, Mexico.
European urology focus
|May 6, 2025
概括
对转移性清细胞细胞癌 (mccRCC) 的最新指南强调免疫检查点抑制剂 (ICI) 组合作为一线治疗. 细胞还原性切除术和积极监测是选择的选择,选择的患者,晚期癌.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 翻译医学是一种翻译医学.
背景情况:
- 转移性清细胞细胞癌 (mccRCC) 是癌症发病率和死亡率的重要原因.
- 治疗范式已经转变为抗血管原氨酸激酶抑制剂 (TKI) 和免疫检查点抑制剂 (ICI).
研究的目的:
- 为mccRCC提供当前国际管理建议的概述.
- 以突出基于最近临床试验证据的不断发展的治疗策略.
主要方法:
- 审查目前关于mccRCC管理的国际准则.
- 来自临床试验的综合证据,涉及系统疗法,细胞还原性切除术和积极监测.
主要成果:
- 前置细胞还原性切除术并非推给所有患者使用,但可能有利于某些具有有限转移负担的患者.
- 对于缓慢生长,无症状,低体积的mccRCC.患者,积极监测是适当的.
- 第一线治疗越来越多地使用基于ICI的组合,根据个体患者的因素量身定制.
- 随后的线路中的治疗序列仍然很复杂,需要进一步研究.
结论:
- 目前的mccRCC管理集成了个性化的方法,优先考虑ICI组合.
- 治疗策略必须适应新出现的证据,需要不断更新指南.
- 基于临床试验的个性化治疗改善了晚期癌患者的治疗结果.
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