量化129XeMRI通风缺陷百分比使用二进制值,高斯线性结合和K-means方法:喘和COPD的差异
Eveline Durom1, Chanwoo Yang2, Ali Mozaffaripour1
1Robarts Research Institute, Western University, London, Canada (E.D., C.Y., A.M., A.M.M., G.P.); School of Biomedical Engineering, Western University, London, Canada (E.D., A.M., G.P.).
Academic radiology
|May 6, 2025
概括
在喘和COPD患者中量化通风缺陷百分比 (VDP) 的不同方法产生显著不同的结果. 这些差异凸显了在使用高极化129XeMRI的多中心研究中需要仔细考虑的需要.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 超极化129XeMRI使用通风缺陷百分比 (VDP) 来量化通风异质性.
- 目前的VDP量化方法包括二进制值 (BT),高斯线性分类 (GLB) 和k-means集群.
- 这些方法尚未在喘和COPD患者中进行直接比较,因为在这些患者中通风缺陷很常见.
研究的目的:
- 在喘和COPD患者中使用四种不同的方法量化和比较VDP.
- 评估不同VDP量化技术之间的一致性和相关性.
主要方法:
- 对175名参与者的数据进行了回顾性分析 (42名健康人,43名COPD,90名喘患者).
- 使用CNN联合注册和细分,GLB,GLBslice,BT和k-means方法量化VDP.
- 使用线性回归和布兰德-阿尔特曼图表来评估方法间的相关性和一致性.
主要成果:
- 在所有组中,在GLB/BT和GLBslice/k-means方法之间观察到VDP的显著差异.
- 使用GLB,GLBslice和BT计算的VDP与k-平均VDP (R2值在0.64到0.84之间) 显示出显著的相关性.
- 布兰德-阿尔特曼分析显示,k-平均值与其他方法之间的一致性具有很大的95%置信区间,特别是在COPD患者中.
结论:
- 选择VDP量化方法显著影响了喘和COPD超极化129XeMRI研究的结果.
- 在多中心研究中,观察到的方法之间的差异需要仔细考虑标准化和解释.
- 进一步研究方法协调对于可靠的临床应用和比较研究至关重要.
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