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Updated: May 5, 2026

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与喉喉逆流性疾病相关的人类声组织修饰:系统性审查
Guangjin Chen1, Jérôme R Lechien2
1Department of Surgery, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.
概括
喉回流性疾病 (LPRD) 导致声组织的细胞损伤,包括DNA损伤和氧化应激. 了解这些变化对于诊断和治疗与LPRD相关的语音障碍至关重要.
科学领域:
- 喉腔病理学 喉腔病理学
- 胃肠病学 胃肠病学
- 病理生理学 病理生理学
背景情况:
- 喉回流性疾病 (LPRD) 是引起声组织变化和失声症的有争议的原因.
- 研究暴露于反流体的人类声组织,为LPRD提供了洞察力.
- 本综述总结了LPRD对声组织的影响.
研究的目的:
- 系统地审查由LPRD引起的人类声组织修饰.
- 了解LPRD病理生理学和相关的语音障碍.
主要方法:
- 对PubMed,Embase和Web of Science数据库进行系统审查.
- 包括调查喉粘膜损伤和与LPRD逆流相关的组织学修饰的研究.
- 遵循系统审查和元分析 (PRISMA) 准则的首选报告项目.
主要成果:
- 24项研究显示,从LPRD患者的声活检中发现了组织学和功能性变化.
- 观察到的变化包括炎症细胞透,细胞结蛋白解,素对DNA造成的损伤和氧化应激增加.
- 观察到有损的防御机制 (例如,碳酸无水酶,粘蛋白) 和组织重塑 (例如,矩阵金属蛋白酶激活).
结论:
- LPRD和素诱导声和喉组织的显著细胞变化.
- 确定了LPRD的潜在致病机制和生物标志物.
- 这些发现可以指导未来的诊断和治疗策略,用于LPRD相关的语音障碍.
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