不和脂肪摄入的时间通过肠道微生物群-胆酸轴改善胰岛素敏感性:一项随机对照试验
Chunbo Wei1, Xiaoqing Xu1, Jia Zhang1
1Department of Nutrition and Food Hygiene, School of Public Health, Key Laboratory of Precision nutrition and health, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, China.
Nature communications
|May 6, 2025
概括
在午餐之前提前摄入不和脂肪 (USFA),可以改善糖尿病前期患者的胰岛素敏感性. 这种效应与肠道微生物组和胆酸代谢的变化有关,无论USFA类型如何.
科学领域:
- 代谢健康 代谢健康
- 营养科学 营养科学
- 肠道微生物组研究研究
背景情况:
- 饮食脂肪的时间影响葡萄糖平衡,但不和脂肪 (USFA) 的影响是未知的.
- 糖尿病前期管理需要了解可修改的饮食因素,如脂肪摄入时间和类型.
研究的目的:
- 调查不和脂肪 (USFA) 时间 (午餐与晚餐) 和类型 (单不和与多不和) 对糖尿病前期血糖代谢的影响.
- 探索USFA摄入时间,葡萄糖代谢和肠道微生物组变化之间的关联.
主要方法:
- 一个为期12周的,双盲,随机对照的2x2因数式养试验,与70名糖尿病前期参与者.
- 评估食后葡萄糖和胰岛素,持续的葡萄糖监测,血清脂肪酸,肠道微生物群和便代谢物.
- 在最终分析中包括60名参与者,并分析了便样本.
主要成果:
- 两组之间餐后葡萄糖没有显著差异.
- 与晚餐摄入量相比,午餐时的USFA摄入改善了胰岛素敏感性,并减少了食后胰岛素和自由和脂肪酸 (P<0.05).
- 这些改善与肠道微生物组和胆酸代谢的改变有关,不论USFA类型.
结论:
- 将不和脂肪 (USFA) 摄入量提前到午餐时段可以提高糖尿病前期患者的胰岛素敏感性.
- 肠道微生物群和胆酸代谢调解USFA定时对胰岛素敏感性的有益影响.
- 饮食脂肪计时是改善糖尿病前期代谢健康的潜在策略.
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