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Updated: May 12, 2025

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
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对NHEJ中Ku70/80和Pol X家族聚合酶之间的相互作用的结构和功能见解

Philippe Frit1, Himani Amin2, Sayma Zahid2

  • 1Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UT3), Toulouse, France.

Nature communications
|May 6, 2025
PubMed
概括

DNA聚合酶lambda和mu对于通过非同类末端连接修复DNA双链断裂至关重要. 新的结构揭示了这些聚合酶如何与Ku70/80相互作用,澄清了它们在DNA修复和细胞生存中的作用.

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