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Updated: May 12, 2025

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
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通过表观遗传激活植物细胞全能性调节器,LEC2诱导体细胞重编程

Jing Peng1, Qi Zhang1, Li Ping Tang1

  • 1National Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an, Shandong, China.

Nature communications
|May 6, 2025
PubMed
概括

在阿拉比多普西斯中过度表达叶子COTYLEDON2 (LEC2) 激活了RNA指导的DNA甲基化 (RdDM) 途径,导致CHH过甲基化. 这种表观遗传修饰增强了染色质的可访问性,并激活了体质胚胎生成的全能基因.

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