在德国的一个基于人口的队列中,对COVID-19后综合征进行全基因组关联研究
Anne-Kathrin Ruß1,2, Stefan Schreiber3, Wolfgang Lieb2
1Institute of Medical Informatics and Statistics, University Medical Center Schleswig-Holstein, Kiel University, Brunswiker Straße 10, 24113, Kiel, Germany.
Scientific reports
|May 6, 2025
概括
遗传因素可能会影响后COVID综合征 (PCS) 风险. 一项全基因组关联研究发现了特定基因变异和PCS严重程度之间的潜在联系,包括嗅觉受体基因,这表明长期COVID患者嗅觉和味觉障碍的遗传基础.
科学领域:
- 遗传学 遗传学 是一个
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 后COVID综合征 (PCS) 或长COVID是一种严重的健康负担,影响COVID-19后12周或更长时间持续症状的个体.
- 鉴定PCS的遗传修饰剂对于理解其复杂的病因和开发有针对性的干预措施至关重要.
- 尽管大流行病的衰退,PCS仍然是一个全球卫生挑战,需要进一步调查其潜在机制.
研究的目的:
- 进行全基因组关联研究 (GWAS),以确定与后COVID综合征 (PCS) 严重程度相关的遗传变异.
- 探索PCS的潜在遗传基础,特别关注诸如嗅觉和味觉障碍之类的症状综合体.
- 为了研究PCS的遗传结构,在一个大规模的,基于人口的队列的SARS-CoV-2感染个体.
主要方法:
- 一个病例控制全基因组关联研究 (GWAS) 在德国的COVIDOM队列中的2,247名参与者身上进行.
- 三个PCS严重性得分,从症状综合体评估的感染后六个月衍生,被二分为GWAS分析.
- 分析了超过630万个单核酸多态 (SNP) 与PCS分数的关联.
主要成果:
- 几种遗传变异与PCS得分有关联,但没有一个达到严格的全基因组显著性 (p <5×10−8).
- SNP rs9792535 (chr9:127,166,653) 几乎没有达到显著性值 (p=6.6×10−8) ,并且位于NEK6,PSMB7和ADGRD2基因附近.
- 嗅觉受体基因区域中的一个主要SNP (rs10893121,chr11:123,854,744;p=2.5×10−6) 表明PCS中嗅觉/味觉功能障碍与遗传联系.
- 其他协会指出病毒抑制,巨细胞激活和病毒颗粒释放的潜在作用.
结论:
- 后COVID综合征的遗传背景是复杂的,可能是多因素的,类似于其他复杂的人类特征.
- 遗传变异,特别是在嗅觉受体基因中,可能导致PCS中出现的持续的嗅觉和味觉障碍.
- 需要进一步的研究来阐明在长期COVID的发展和表现中涉及的特定遗传因素和生物途径.
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