在不同的葡萄糖代谢状态下,甘油三糖量调整后腰部指数和中风风险之间的关联
Guijun Huo1, Ziyi Tan1, Yao Tang1
1The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 26 Daoqian Street, Suzhou, Jiangsu, China.
Scientific reports
|May 6, 2025
概括
甘油三糖重量调整腰部指数 (TyG-WWI) 与中国成年人中风风险增加有关. 这种关联在糖尿病前期患者中特别强烈,突出显示了它作为中风风险指标的潜力.
科学领域:
- 心血管疾病流行病学
- 代谢综合征研究 代谢综合征研究
- 公共卫生与老年学
背景情况:
- 胰岛素抵抗 (IR) 是代谢障碍和心血管事件的关键因素.
- 甘油三糖重量调整腰部指数 (TyG-WWI) 是一种新的IR标志物.
- TyG-WWI与中风发病率之间的关联,特别是在不同的葡萄糖代谢状态之间,需要进一步研究.
研究的目的:
- 评估TyG-WWI指数与中风风险之间的关系.
- 探索这种关联是否根据葡萄糖代谢状态 (正常的葡萄糖调节,糖尿病前期,糖尿病) 不同.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) 的数据.
- 采用多变量考克斯比例危险模型和受限立方线 (RCS) 分析.
- 分析了8895名参与者的数据,记录了831次中风事件.
主要成果:
- 在TyG-WWI中,一个标准偏差的增加与中风风险增加11%有关 (HR: 1.11).
- 与最低四分位数相比,TyG-WWI的较高四分位数显示中风风险显著增加.
- 高TyG-WWI和中风风险之间的关联在糖尿病前期是显著的,但在正常血糖调节或糖尿病组中没有.
结论:
- TyG-WWI指数与中年和老年中国人中风风险有显著的相关性.
- TyG-WWI与中风风险之间的关系是由葡萄糖代谢状态调节的,在糖尿病前期最为突出.
- TyG-WWI可以作为一种有价值的指标,用于识别患中风风险较高的个体,尤其是糖尿病前期患者.
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