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在患有牙周炎的个体中,细菌转位特征和下微生物群

Marcelo Britos¹, Marcela Hernández^1,2, Alejandra Fernández³

¹Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Olivos 943, Independencia, Santiago, 8380544, Chile.

Clinical oral investigations

|May 6, 2025

概括

患有牙周炎的个体在血液中表现出较高的Porphyromonas endodontalis (Pe) 负载,这表明潜在的系统联系. 需要进一步的研究来澄清 subgingival 和血液细菌水平之间的关系.

科学领域:

微生物学微生物学
牙周病学牙周病学
口腔健康口腔健康

背景情况:

牙周炎是一种常见的炎症性疾病,影响牙.
细菌从口腔转移到血液中是一种潜在的机制,可以将牙周炎与全身疾病联系起来.

研究的目的:

为了研究带有牙周炎和没有牙周炎的个体血液中的细菌转位特征.
为了检查 subgingival微生物群和血液中的细菌存在之间的联系.

主要方法:

一项涉及21名牙周炎患者和24名对照者的横截面研究.
16S rRNA基因测序用于下微生物群分析.
定量PCR (qPCR) 用于检测和量化血液和下样本中的总细菌, Porphyromonas gingivalis (Pg), Porphyromonas endodontalis (Pe) 和 Fusobacterium nucleatum (Fn).

主要成果:

牙周炎患者在下样本中显示出明显更高的特定细菌的相对丰度和负载,包括Pg,Pe和Fn.
在大多数参与者的血液中检测到Pe,在牙周炎患者中观察到的负载明显更高.
血液样本中没有检测到Pg和Fn,并且没有发现下下和血液Pe负载之间的显著相关性.

结论:

患有牙周炎的个体在血液中增加了Pe的负载,这表明潜在的口外传播.
这些发现表明牙周炎,细菌转移和全身性疾病之间可能存在联系.
需要进一步调查,以阐明 subgingival 和全身细菌负载之间的准确相关性.

关键词:

细菌病是什么意思细菌病是什么意思细菌负载的细菌负载.牙周病是指牙周病的发生.下微生物组下微生物组

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