肠道微生物群和癌症:从瘤发生到治疗
Amandine Nobels1,2, Cédric van Marcke2,3,4, Bénédicte F Jordan5
1UCLouvain, Université catholique de Louvain, Louvain Drug Research Institute (LDRI), Metabolism and Nutrition Research Group (MNUT), Brussels, Belgium.
Nature metabolism
|May 6, 2025
概括
肠道微生物群通过与免疫系统相互作用,影响癌症的发展和治疗反应. 了解这些肠道细菌的相互作用是改善癌症治疗和患者治疗结果的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 肠道微生物组在癌症的发展和治疗中起着重要作用.
- 它与免疫系统和瘤微环境的相互作用至关重要.
- 肠道微生物群对调节治疗反应的确切影响需要进一步阐明.
研究的目的:
- 审查当前对肠道微生物组参与癌症的理解.
- 为了掩盖其在瘤启动,进展和对各种癌症治疗的反应中的作用.
- 讨论潜在的基于微生物群的癌症治疗策略.
主要方法:
- 关于肠道微生物组和癌症的当前知识的文献综述.
- 综合有关微生物代谢物,特定细菌物种和治疗结果的信息.
- 探索饮食干预,益生菌和便微生物群移植.
主要成果:
- 肠道微生物群影响癌症的发病,进展以及对化疗,放射治疗和向治疗的反应.
- 微生物代谢物显著影响瘤微环境中的免疫反应.
- 特定的细菌物种与不同的治疗结果有关.
结论:
- 了解肠道微生物群和免疫系统之间的复杂相互作用对于优化癌症疗法至关重要.
- 需要进一步的研究来确定能够预测治疗成功的微生物特征.
- 有针对性的微生物组调制策略有望提高癌症护理患者的治疗结果.
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